Which word best describes someone who is artful and cunning?

The word "wily" indeed captures the essence of someone who is artful and cunning. It describes a person who is skilled at using clever tactics to achieve their goals, often employing tricks or deceit to outsmart others. This term highlights a level of craftiness and shrewdness, suggesting that the individual is adept at maneuvering through situations to their advantage.

In contrast, the other options—such as "honest," "naive," and "simple"—do not align with the characteristics of being cunning or artful. "Honest" describes a straightforward and truthful individual, while "naive" suggests an innocent or lacking in experience person who may not understand the complexities of a situation. "Simple" refers to someone who is uncomplicated or lacking sophistication, which is in direct opposition to the cleverness implied by being wily. Therefore, "wily" is the best fit for the description provided.